healthy male regular smokers. tobacco-related carcinogen detoxification
Conditions
Interventions
Oral intake of 4 cups of Nutri-PEITC jelly per day for 3 consecutive days
Experimental Dietary Supplement
Sponsors
Mahidol University
Eligibility
Sex/Gender
Male
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Thai men aged 20-60 years, 2. No systemic disease that cannot be controlled or untreated, 3. Smoking 5-45 cigarettes per day for 1-10 years, 4. No history of psychiatric disorders, 5. Use only cigarettes (no other narcotics), 6. No medications affecting cytochrome P450 1A2, 2A6 and 2A13 such as antidepressants, antihypertensive drugs, calcium channel blockers such as varapamil. Beta blockers such as propranolol, anticoagulants such as warfarin and tricloidine, antibiotics such as ciprofloxacin and fluoroquinolores, and opioid analgesic drugs, 7. BMI between 18-30 kg/ m2, 8. Normal blood laboratory tests include kidney function (BUN, creatinine), liver function (AST, ALT, total bilirubin), blood lipid levels, normal blood sugar levels and complete blood count, 9. Able to communicate well and give informed consent in writing, 10. Able to consume Nutri-PEITC jelly, 11. Able to avoid eating cruciferous vegetables such as watercress, kale, cabbage, broccoli, Chinese cabbage, cauliflower, radishes, mustard, and wasabi, 12. Able to avoid drinking alcoholic beverages at least 24 hours before enrolling in the study and throughout the study period.
Exclusion criteria
Exclusion criteria: 1. Having cancer or a history of cancer, 2. Having liver or kidney diseases, 3. Taking paracetamol, chlorazone (ChlorzOXaZone) and Enceasein (N-acetylcysteine) within 24 hours before participating in the study and throughout the study period.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in NNAL metabolites in urine before and after 3 days of intervention LC-MS/MS,Adverse events after 3 days of intervention observation of adverse event, subject diaries | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in NNN metabolites in urine before and after 3 days of intervention LC-MS/MS analysis | — |
Countries
Thailand
Contacts
Public ContactDunyaporn Trachootham
Mahidol University
Outcome results
None listed