Effect of oral dexamethasone for prevention of postembolization syndrome after hepatic conventional transarterial chemoembolization: A prospective randomized, double blinded, placebo controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210518001

Enrollment

Registered

2021-05-18

Start date

2021-05-23

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postembolization syndrome after hepatic conventional transarterial chemoembolization Postembolization syndrome

Interventions

Dexamethasone 4 mg 3 tab po 30 min before TACE Dexamethasone 4 mg 1 tab po bid pc x 2 days,Placebo 3 tab po 30 min before TACE Placebo 1 tab po bid pc x 2 days

Active Comparator Drug,Placebo Comparator Drug

Dexamethasone group,Placebo group

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Hepatocellular carcinoma 2. Child-Pugh score <= 7 3. Indication for treatment with TACE

Exclusion criteria

Exclusion criteria: 1.Main portal vein thrombosis 2.SMV and IVC thrombosis 3.Hepatosystemic shunt 4.Tumor size > 50% of liver or > 10 cm 5.Bile duct obstruction 6.UGIH 7.Ascites 8.HR<50/min 9.TB>3mg/dl 10.ANC<1500 11.Platelet<80,000 12.INR>1.5 13.Cr>2 14.Uncontrolled heart disease 15.Active infection 16.HIV infection 17.Uncontrolled DM 18.Untreated HBV infection 19.Fever or nausea/vomiting 20.Steroid or NSAIDs use 21.Other malignancy within 3 years 22.Pregnancy

Design outcomes

Primary

Measure	Time frame
Efficacy for prevention of postembolization syndrome 1 week Score by Southwest oncology group toxicity coding	—

Secondary

Measure	Time frame
Quality of life 1 week EORTC QLQHCC18 and FACT-Hep questionaires	—

Countries

Thailand

Contacts

Public ContactNarasak Changraksa

Khon Kaen University

narasak_nak@hotmail.com0846042299

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026