The immune response after COVID-19 vaccine administration in healthy volunteers. COVID-19 vaccine, Sputnik V, ChAdOx1, coronavac, Sinovac.
Conditions
Interventions
Administration Gam-COVID-Vac 0.5 ml intramuscular at deltoid muscle for 2 doses with a 3-week interval.,Administration CoronaVac 0.5 ml intramuscular at deltoid muscle for 2 doses with a 3-week interv
Gam-COVID-Vac,CoronaVac,ChAdOx1
Sponsors
Chulabhorn Royal Academy
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. 18 years old or more 2. negative for blood SARS-CoV-2 antibody 3. negative for nasopharynx PCR for SARS-CoV-2 4. Negative urine pregnancy test (in case of potential of pregnancy) 5. No history of a severe allergic reaction to the prior vaccine. 6. No fever nor history of fever within 14 days. 7. No symptom of respiratory tract infection within 14 days. 8. ECOG 0,1 9. sign informed consent to the study.
Exclusion criteria
Exclusion criteria: 1. prior COVID-19 vaccination. 2. Vaccination with any vaccines within 30 days 3. administration of steroid or receive immunoglobulins within 30 days 4. Receive immunosuppression agent within 30 days. 5. pregnancy. 6. lactation. 7. acute coronary syndrome in the past year. 8. Acute stroke in the past year. 9. Splenectomy 10. active chronic infectious disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antibody level of total antibody of spike protein of SARS-CoV-2 1 month after the second dose of the vaccine Double antigen technique for detection of Antibody level of total antibody of spike protein of SARS-CoV-2 | — |
Secondary
| Measure | Time frame |
|---|---|
| sustainability of antibody level 12 month after the second dose of the vaccine Double antigen technique for detection of Antibody level of total antibody of spike protein of SARS-CoV-2,proportion of seroconversion after vaccination 1 month after the second dose of the vaccine Double antigen technique for detection of Antibody level of total antibody of spike protein of SARS-CoV-2,T cell respond after vaccination 1 month after the second dose of the vaccine interferon gamma releasing assay,seroprevalence of adenovirus infection Before vaccination. Qualitative measurement of adenovirus antibody.,proportion of the volunteers had four-fold rising of antibody level after vaccination 1 month after the second dose of the vaccine Double antigen technique for detection of Antibody level of total antibody of spike protein of SARS-CoV-2 | — |
Countries
Thailand
Contacts
Public ContactKriangkrai Tawinprai
HRH Princess Chulabhorn College of Medical Science
Outcome results
None listed