Patients aged at least 20 years old with history of low back pain and/or leg pain who fail conservative treatments (including medications, bed rest, activity modification and/or physical therapy). low back pain sciatica pain epidural steroid injection inflammatory cytokine
Conditions
Interventions
Pain relief at least 50% or neck functional improve at least 50% after ESI at 2-week follow up,Pain relief less than 50% or neck functional improve less than 50% after ESI at 2-week follow up
Treatment,Treatment
Responder ,Non responder
Sponsors
Pornpan Chalermkitpanit
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Low back pain with/without leg pain 2. Pain score at least 4 out of 10 after conservative treatments (medication, rehabilitation, bed rest)
Exclusion criteria
Exclusion criteria: 1. Previous lumbar spine surgery 2. Compression fracture or trauma 3. Patients with red flags signs (progressive weakness, infection, tumor, bowel/bladder symptoms) 4. Patients diagnosed of systematic inflammatory diseases (rheumatoid arthritis, inflammatory arthritis, ankylosing spondylitis, etc.) 5. Contagious disease (COVID-19 infection) 6. Allergic to medication 7. Diagnosis of depression 8. Taking oral steroid medications 9. History of prior epidural steroid injection in last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of serum cytokines at 2 weeks after epidural steroid injection (ESI) mmol/l,Pain score at 2 weeks after epidural steroid injection (ESI) Visual Analog Score (VAS), 0-10 | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of pain relief 50% pain relief weeks,incidence of spine surgery at 6 months after ESI weeks,Correlation of severity of MRI and serum cytokine concentration at 2 weeks after ESI ratio | — |
Countries
Thailand
Contacts
Public ContactPornpan Chalermkitpanit
Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed