Optical coherence tomography angiography findings in patients with acute non-arteritic central retinal artery occlusion treated with carbogen inhalation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20210510007

Enrollment

Registered

2021-05-10

Start date

2021-05-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-arteritis central retinal artery occlusion Central retinal artery occlusion Optical coherence tomography angiography Carbogen

Interventions

Patients with acute non-arteritic CRAO treated with carbogen inhalation, topical anti-glaucoma and ocular massage.

Treatment

CRAO

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with acute (within 7 days from onset) non-arteritic central retinal artery occlusion presented at Songklanagarind hospital from 1 January 2021 to 31 June 2022

Exclusion criteria

Exclusion criteria: 1. Patients with acute ocular comorbidity warranting other acute management i.e., giant cell arteritis receiving IV steroid or combined with central retinal vein occlusion 2. Patients previously treated with carbogen inhalation 3. Unable to perform OCTA due to in-cooperation, dense cataract, unable to sit upright etc. 4. Pregnancy of any trimester 5. Chronic obstructive pulmonary disease 6. Patients under going any other clinical trials

Design outcomes

Primary

Measure	Time frame
Vessel density Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical coherent tomography angiography,Flow area Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical coherent tomography angiography,Foveal vessel density Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical coherent tomography angiography,Central macular thickness Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical tomography angiography	—

Measure

Time frame

Vessel density Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical coherent tomography angiography,Flow area Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical coherent tomography angiography,Foveal vessel density Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical coherent tomography angiography,Central macular thickness Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Optical tomography angiography

—

Secondary

Measure	Time frame
Visual acuity Before, 12-24 hours, 36-48 hours, 1-2 weeks, 4-6 weeks after carbogen inhalation Snellen chart	—

Countries

Thailand

Contacts

Public ContactPongrapee Atipas

Department of Ophthalmology, Songklanagarind Hospital

atipas.p@gmail.com0934274000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026