Liver stiffness after 1-year follow-up in patients with non-alcoholic fatty liver disease and chronic hepatitis C infection with sustained virological response after DAA therapy. Liver stiffness, Chronic hepatitis C, Direct-acting anti-viral Sustained virological treatment Non-alcoholic fatty liver disease
Conditions
Interventions
Patients with chronic hepatitis C or non-alcoholic fatty liver disease at day 0.,Patients with chronic hepatitis C or non-alcoholic fatty liver disease at 1-year follow-up.
Other,Other
Baseline,One-year follow-up
Sponsors
King Chulalongkorn Memorial Hospital, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Chronic hepatitis C patients treated with a course of 12- or 24-week of DAA therapy and achieve sustained virological response at 12 weeks after treatment completion or 2) Non-alcoholic fatty liver disease confirmed by histology or imaging 3) Age more than 18 years
Exclusion criteria
Exclusion criteria: 1) Alcohol drinking more than 14 units/week in males or 7 units/week in females. 2) HIV co-infection 3) HBC co-infection 4) Other causes of chronic liver diseases eg. autoimmune hepatitis, hemochromatosis, Wilson's disease, or vascular liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean change of liver stiffness value 1 year Simple serum biomarker scores and liver stiffness evaluated by Fibroscan, ultrasound elastography and magnetic resonance elastography | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation of liver stiffness value evaluated by three elastography techniques 1 year Fibroscan, ultrasound elastography and magnetic resonance elastography | — |
Countries
Thailand
Contacts
Public ContactKessarin Thanapirom
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and Thai Red Cross, King Chulalongkorn Memorial Hospital, Pathumwan, Bangkok 10330, Thailand
Outcome results
None listed