We will study healthy volunteer if calcium carbonate can reduced functional fecal levofloxacin and protect fecal microbiome or not. 1.Levofloxacin 2.Calcium carbonate 3.fecal functional level of levofloxacin 4. Microbiota diversity 5. Maximal plasma levofloxacin concentration(C max)
Conditions
Interventions
Taking 1000 mg oral tablet calcium carbonate twice daily before meal (1st dose on 12:00-1:00 p.m. and 2nd dose 6:00-7:00 p.m.) duration for 6 days and start 1 day before levofloxacin.
Taking 500 mg or
Experimental Drug,No Intervention No treatment
Calcium carbonate,No calcium carbonate
Sponsors
Royal College of Physician Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteer male or female age more than or equal 18 but less than 45 years old 2. No underlying disease 3. No history of receiving any medication within 1 month and no history of antibiotic use within 3 months 4. No history of drug allergy 5. Able to swallowing tablet medicine 6. No constipation 7. Body mass index range 18-25 kg/m2 8. eGFR (MDRD) > 60 ml/min/1.73m2 9. Normal liver function test, evaluated by physician
Exclusion criteria
Exclusion criteria: 1 During pregnancy or lactation 2 Use of mineral or vitamin or herbal medicine supplementation within 1 month, especially metal compound such as iron, zinc, magnesium, calcium, aluminium or any vitamin etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fecal functional level of levofloxacin 1 month after the end of intervention geometric mean and T test | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota diversity in healthy volunteers taking levofloxacin for 5 days by 16s rDNA sequencing 1 month after intervention T test | — |
Countries
Thailand
Contacts
Public ContactOphat Janphet
Division of Infectious Disease, Department of Medicine, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed