The patients with unstable ankle fractures who have surgical indications. Analgesia Ankle fractures parecoxib perioperative randomised controlled trial
Conditions
Interventions
Group A, parecoxib 40 mg IV 30 min before surgery and then additional 40 mg every 12 hours for 48 hours after surgery , Group B, placebo or normal saline 10 ml, IV 30 min before surgery and then addit
Active Comparator Drug,Placebo Comparator Drug
Perioperative Parecoxib, intravenous injections,Normal saline, intravenous injection
Sponsors
American Orthopaedic Foot & Ankle Society
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: The patient with unstable ankle fracture who had the indication for open reduction and internal fixation.
Exclusion criteria
Exclusion criteria: The contraindication of parecoxib use (1 pateint), thrombocytopenia on preoperative blood work (1 patient), head injury with contraindication for spinal anesthesia (1 patient), and acute on chronic fracture (1 patient).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain and related scores, amount of morphine used Time 0 was recorded when the patients were move to the post-anesthesia care unit (PACU) after surgery. The VNRS and VNRP were recorded at 0, 4, 12, 24 and 48 hours after surgery by trained personnel. verbal numerical rating score, verbal numerical rating percentage, patient subjective rating of the medication, amount of intravenous morphine administered, overall adverse effects | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactChayanin Angthong
Thammasat University
Outcome results
None listed