Evaluation of safety and effect of Anethum graveolens Linn. (Dill) extract beverage against stress in working age volunteers

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210407002

Enrollment

Registered

2021-04-07

Start date

2021-08-09

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Conditions Anethum graveolens Dill stress working memory cognitive processing

Interventions

Subjects are received placebo beverage once daily for 6 weeks,Subjects are received Anethum graveolens Linn. (Dill) extract beverage 1,000 mg/day once daily for 6 weeks,Subjects are received Anethum g

Placebo Comparator Other,Experimental Dietary Supplement,Experimental Dietary Supplement

Placebo,Subjects are received Anethum graveolens Linn. (Dill) extract beverage 1,000 mg/day,Subjects are received Anethum graveolens Linn. (Dill) extract beverage 1,500 mg/day

Eligibility

Sex/Gender

All

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1.Aged between 20 -55 years old 2.Body Mass Index (BMI) 18.5-25 kg/m2 3.DASS-21 score more than 10

Exclusion criteria

Exclusion criteria: 1.Volunteers who have been diagnosed with one of the following; diabetes mellitus, cardiovascular diseases, liver disease, kidney disease, respiratory diseases, autoimmune disease and neuropsychological diseases 2.Volunteers who require supplements or any drug that effect on the nervous system by order of the doctor before trial 3.Volunteers who use hormone or any drug that effect on the nervous system during 3 month before the test 4.Smoking more than 10 pieces/ day 5.Drinking alcohol more than 5 times/ day 6.Volunteers who participate in other projects

Design outcomes

Primary

Measure	Time frame
Depression Anxiety Stress Scale 21 Thai 6 weeks DASS-21 Thai questionnaire	—

Secondary

Measure	Time frame
The changes of hematological and clinical chemistry parameters 6 weeks laboratory,Acetylcholinesterase (AChE), Monoamine oxidase (MAO), Monoamine oxidase type A (MAO-A) and GABA-T 6 weeks laboratory,Oxidative stress markers; Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) 6 weeks laboratory,Inflammatory markers (IL-6, CRP) 6 weeks ELISA method,Physical fitness 6 weeks equipment,Evaluation of sleep quality 6 weeks Thai version of the Pittsburgh Sleep Quality Index, T - PSQI,Evaluation of Mood 6 weeks MOSAIC questionnaire,N100 and P300 6 weeks Event related evoked potentials (ERPs),Working memory test 6 weeks Computerized batteries test ,The changes of electrocardiogram 6 weeks Electrocardiography	—

Measure

Time frame

The changes of hematological and clinical chemistry parameters 6 weeks laboratory,Acetylcholinesterase (AChE), Monoamine oxidase (MAO), Monoamine oxidase type A (MAO-A) and GABA-T 6 weeks laboratory,Oxidative stress markers; Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) 6 weeks laboratory,Inflammatory markers (IL-6, CRP) 6 weeks ELISA method,Physical fitness 6 weeks equipment,Evaluation of sleep quality 6 weeks Thai version of the Pittsburgh Sleep Quality Index, T - PSQI,Evaluation of Mood 6 weeks MOSAIC questionnaire,N100 and P300 6 weeks Event related evoked potentials (ERPs),Working memory test 6 weeks Computerized batteries test ,The changes of electrocardiogram 6 weeks Electrocardiography

—

Countries

Thailand

Contacts

Public ContactWipawee Thukhammee

Khon Kaen University

wipath@kku.ac.th0850016805

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026