Early stage breast cancer post breast conserving surgery Breast cancer Hypofractionation Radiation
Conditions
Interventions
42.5 Gy in 16 fractions with boost 10 Gy in 4 fractions,40 Gy in 10 fractions
Standard hypofractionated radiotherapy,Accelerated hypofractionated radiotherapy
Sponsors
Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn university
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Women age > 18 years 2. Early-stage invasive breast cancer (T1-2, N0, M0) and Ductal Carcinoma In Situ 3. Post breast conserving surgery with negative surgical margins 4. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
Exclusion criteria
Exclusion criteria: 1. Received previous breast irradiation 2. Received breast reconstruction 3. Received neoadjuvant therapy 4. Bilateral breast cancer 5. Other malignancy before diagnosis which can interfere the treatment outcome 6. Hereditary breast cancer 7. Active connective tissue disease 8. Pregnancy or lactation 9. Unable or unwilling to give inform consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| local recurrence at 3 years and 5 years after end of the intervention Imaging and biopsy proved | — |
Secondary
| Measure | Time frame |
|---|---|
| Toxicity Acute toxicity: 1 and 3 months after complete treatment , late toxicity: 6 months after complete treatment The RTOG Acute radiation scoring criteria and the ROTG/EORTC late radiation Morbidity Scoring Scheme | — |
Countries
Thailand
Contacts
Public ContactKanjana Shotelersuk
Division of Radiation Oncology, Radiology department, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed