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The Effect of Preoperative Submucosal Administration of Dexamethasone Tramadol Articaine on The Success Rate of Inferior Alveolar Nerve Block on Mandibular Molars With Symptomatic Irreversible Pulpitis A Randomized Double Blind Placebo Controlled Clinical Trial

The Effect of Preoperative Submucosal Administration of Dexamethasone Tramadol Articaine on The Success Rate of Inferior Alveolar Nerve Block on Mandibular Molars With Symptomatic Irreversible Pulpitis A Randomized Double Blind Placebo Controlled Clinical Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210326008
Enrollment
120
Registered
2021-03-26
Start date
2020-01-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

It is difficult to provide complete pulpal anesthesia in mandibular molars with irreversible pulpitis. To establish the effects of submucosal tramadol, dexamethasone, articaine on the success of inferior alveolar nerve block in the endodontic treatment of mandibular molars with symptomatic irreversible pulpitis. submucosal tramadol submucosal dexamethasone submucosal articaine anesthesic success inferior alveolar nerve block endodontic treatment irreversible pulpitis

Interventions

After administration of local anesthesia and before starting treatment
submucosal 2 ml saline were administrated to the mucobuccal fold of mandibular molar in control group.,After administration of local anesthesia and before starting treatment
submucosal 100 mg/2 ml tramadol was administrated to the mucobuccal fold of mandibular molar in tramadol group.,After administration of local anesthesia and before starting treatment
submucosal 8 mg/2 ml dexamethasone was administrated to the mucobuccal fold of mandibular molar in dexamethasone group.,After administration of local anesthesia and before starting treatment
submucosal 2 ml articaine was administrated to the mucobuccal fold of mandibular molar in dexamethasone group.
Placebo Comparator Other,Experimental Other,Experimental Other,Experimental Other
Control,Submucosal Tramadol, Submucosal Dexamethasone, Submucosal Articaine

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria included systemically healthy patients, aged between 18 and 65 years, having mandibular molars with symptomatic irreversible pulpitis, preoperative pain score ranging from moderate to severe on a Heft-Parker visual analog scale, radiographically normal periapical area and no pain on percussion.

Exclusion criteria

Exclusion criteria: The exclusion criteria comprised: pregnant or breastfeeding women, patients with allergy, sensitivity or adverse reactions to the medications administered in this study, those who had taken an analgesic or anti-inflammatory drug within last 12 hours before the treatment, those with unrestorable teeth, teeth with periodontal disease, root resorption, open apex, calcified root canals and pulpal necrosis.

Design outcomes

Primary

MeasureTime frame
success of pulpal anesthesia During the endodontic treatment HP VAS Scale—

Secondary

MeasureTime frame
duration of anesthesia ending the anesthesia total time (minutes)—

Countries

Turkey

Contacts

Public ContactFatih Aksoy

Adiyaman University, Faculty of Dentistry, Department of Endodontics

dr.f.aksoy@gmail.com90542 342 88 07

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026