A Role of Preoperative Oral Antibiotics in Reducing Surgical Site Infection Rate in Patient Undergoing Elective Colorectal Surgery in Ramathibodi Hospital: A Randomized-controlled Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210324003

Enrollment

750

Registered

2021-03-24

Start date

2020-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical site infection rate Oral antibiotic Mechanical bowel preparation Colorectal surgery

Interventions

Oral metronidazole 1,000 mg without mechanical bowel preparation before colorectal surgery,No oral antibiotic administered

Experimental Drug,Experimental No treatment

Oral antibiotic,No oral antibiotic

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age > 18 years 2. Patients with colon and rectal disease with indication for surgery 3. No mechanical bowel preparation 4. Open colorectal surgery as standard technique 5. Agree for informed consent

Exclusion criteria

Exclusion criteria: 1. Age > 80 years 2. Allergic to metronidazole 3. Emergency operation 4. Malnutrition 5. Reject to sign informed consent

Design outcomes

Primary

Measure	Time frame
Surgical site infection in 30 days in 30 days after intervention Surgical site infection event	—

Secondary

Measure	Time frame
Readmission rate at 30 days after intervention Readmission event	—

Countries

Thailand

Contacts

Public ContactKrissadee Napapongsa

Facult of Medicine, Ramathibodi Hospital

krisadeen@gmail.com0843275955

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026