nefopam infusion nefopam infusion
Conditions
Interventions
Nefopam infusion postoperatively
20 mg in NSS up to 100 ml IV drip in 1 hr q 6 or 8 hr for 24 hr,NSS infusion postoperatively, 100 ml IV drip in 1 hr q 6 or 8 hr for 24 hr
Experimental Drug,Placebo Comparator Drug
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age 18 years old or more 2.Undergo unilateral TKA 3.ASA physical status I, II, III 4.Have a contraindication to NSAIDs (sulfonamide allergy, CAD, CVA, Creatinine Clearance less than 50 ml/min) 5.Able to use patient-controlled analgesia (IV PCA) 6.Understand the Thai language 7.Willing to enroll
Exclusion criteria
Exclusion criteria: 1.Have a contraindication to nefopam: epilepsy, monoamine oxidase (MAO) inhibitors user, selective serotonin reuptake inhibitor user, glaucoma 2.Have a contraindication to regional anesthesia 3.Liver disease (Child-Pugh classification B or C) 4.Allergy to the drugs used in the research protocol: fentanyl, morphine, lidocaine, bupivacaine, paracetamol, dexamethasone, gabapentin 5.Chronic opioid use, drug abuse 6.Long-term use of NSAIDs, other drugs that may interfere with the research result
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| opioid consumption 48 hours postoperatively microgram of fentanyl from patient control analgesia device | — |
Secondary
| Measure | Time frame |
|---|---|
| pain scores 48 hours postoperatively numerical rating score | — |
Countries
Thailand
Contacts
Public ContactPathom Halilamien
Faculty of Medicine Siriraj hospital
Outcome results
None listed