Hypersensitivity reactions in patients who received taxane chemotherapy regimen between standard premedication protocol and modified premedication protocol without ranitidine. Hypersensitivity reactions in patients who received taxane chemotherapy regimen between standard premedication protocol and modified premedication protocol without ranitidine.
Conditions
Interventions
Schedule of modified premedication without ranitidine protocol
1.Dexamethasone 20 mg intravenous
2.Ondansetron 8 mg oral
3.Diphenhydramine 50 mg oral
4.CPM 10 mg intravenous ,Schedule of standard pre
modified premedication without ranitidine protocol,standard premedication protocol
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Cancer patients who received taxane chemotherapy regimen
Exclusion criteria
Exclusion criteria: 1.History of severe Hypersensitivity reactions from taxane regimen 2.Severe hepatic impairment (bilirubin >5xULN or AST/ALT >10xULN)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypersensitivity reactions every 3 week of six-cycle course of chemotherapy grading of Hypersensitivity reactions | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactChaichana Chantharakhit
Division of Medical Oncology, Department of Medicine, Buddhasothorn Hospital, Chachoengsao, Thailand
Outcome results
None listed