pacemaker induced left ventricular dysfunction pacemaker induced left ventricular dysfunction
Conditions
Interventions
Patients with total AV block who experience LV dysfunction due to right ventricular septal pacemaker implantation as assessed by GLS at 1 and 3 months
Basic Science
left ventricular dysfunction
Sponsors
Self-funded
Eligibility
Sex/Gender
All
Age
19 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female aged >18 years old that was diagnosed with total AV block and will be implanted with a permanent pacemaker in the right ventricular septum 2. EF >50% and TAPSE >16 mm 3. Agree for follow up after pacemaker implantation 4. Written informed consent obtained from the patient
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Myocardial infarction or revascularization therapy in the last 3 months 3. Permanent AF 4. Heart valve disease with significant hemodynamic consequences 5. Abnormal heart structure changes including the right atrium, left atrium, right ventricle, or left ventricle dilation. 6. NYHA function class III or IV 7. Significant respiratory disease 8. Carcinoma in the last 5 years 9. Autoimmune disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| biomarker level changes in patients with total AV block who experienced LV dysfunction due to right ventricular septal pacemaker implantation as assessed by GLS at 1 and 3 months 1 and 3 months ELISA and RT-qPCR | — |
Secondary
| Measure | Time frame |
|---|---|
| difference in biomarker levels between patients with total AV block who experience and do not experience LV dysfunction due to right ventricular septal pacemaker implantattion assessed by GLS 1 and 3 months ELISA and RT-qPCR | — |
Countries
Indonesia
Contacts
Public ContactSidhi Laksono
Faculty of Medicine, University of Indonesia
Outcome results
None listed