Efficacy of aerosol therapy via high-flow nasal cannula with vibrating mesh nebulizer vs. conventional jet nebulization in stable COPD patients: A randomized cross-over trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210317006

Enrollment

Registered

2021-03-17

Start date

2021-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with stable COPD Bronchodilator COPD High-flow oxygen therapy Mesh nebullizer

Interventions

Salbutamol 4 mL will be administered via high-flow nasal cannula connected with vibrating mesh nebulizer,Salbutamol 4 mL will be administered via small volume jet nebulizer with oxygen flow rate of 6

Experimental Device,Active Comparator Device

High-flow nasal cannula,Small volume jet nebulization

Eligibility

Sex/Gender

All

Age

40 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age >/= 40 years old 2. Diagnosed COPD according to GOLD criteria 3. Irreversible airflow obstruction 4. Post-bronchodilator FEV1 between 35-80 %predicted

Exclusion criteria

Exclusion criteria: 1. History of acute exacerbation of COPD or lower respiratory tract infection within 4 weeks 2. Contraindications for spirometry 3. Allergy to salbutamol 4. Pregnant woman 5. Deny to participate

Design outcomes

Primary

Measure	Time frame
Force expiratory volume at 1 second 15 minutes Spirometry	—

Secondary

Measure	Time frame
Total lung capacity 15 minutes Body plethysmography,Airway resistance 15 minutes Impuse oscillometry	—

Countries

Thailand

Contacts

Public ContactNuttapol Rittayamai

Faculty of Medicine Siriraj Hospital

nuttapol.rit@mahidol.ac.th024197757

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026