Evaluation of safety and effect of Morus alba leaf extract mixed with Persicaria odorata on cognitive processing in elderly volunteers

Status

Unknown

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210316013

Enrollment

Registered

2021-03-16

Start date

2021-09-07

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy conditions healthy conditions

Interventions

Subjects are received the placebo product which has same color and smell look like the functional drink containing Morus alba leaf extract mixed with Persicaria odorata,Subjects are received functiona

Placebo Comparator Dietary Supplement,Experimental Dietary Supplement,Experimental Dietary Supplement

Placebo,Functional drink containing Morus alba leaf extract mixed with Persicaria odorata 1,000 mg/day,Functional drink containing Morus alba leaf extract mixed with Persicaria odorata 1,500 mg/day

Eligibility

Sex/Gender

All

Age

60 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Aged between 60-70 years old 2.Body Mass Index (BMI) 18.5-25 kg/m2 3.Blood pressure less than 140/90 mm Hg and Fasting Blood Sugar (FBS) after fasts for 8 hours less than 126 mg/dL

Exclusion criteria

Exclusion criteria: 1.Volunteers who have been diagnosed with one of the following; cardiovascular diseases, respiratory diseases, neuropsychological diseases, liver disease, autoimmune disease and hematological disorder 2.Volunteers who require supplements or any drug that effect on the nervous system by order of the doctor before trial 3.Volunteers who use hormone or any drug that effect on the nervous system and skeletal system before trial 4.Smoking more than 10 pieces/ day 5.Drinking alcohol more than 5 times/ day 6.Volunteers who participate in other projects

Design outcomes

Primary

Measure	Time frame
N100 and P300 Event related evoked potentials (ERPs) Event related evoked potentials (ERPs)	—

Secondary

Measure	Time frame
Working memory test 8 weeks Computerized batteries test ,Acetylcholinesterase and Monoamine oxidase enzyme (MAOA and MAOB) 8 weeks Laboratory,Oxidative stress markers include Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) 8 weeks Laboratory,Serum bone markers include Osteocalcin, Calcium and Beta CTX 8 weeks Laboratory,The changes of hematological and clinical chemistry parameters 8 weeks Laboratory,Stool examination (PH, Total lactic acid, Bifidobacterial, Short chain fatty acid) 8 weeks Laboratory,Evaluation of sleep quality 8 weeks Pittsburgh Sleep Quality Index questionnaire,Evaluation of Stress 8 weeks Perceived Stress Scale - PSS questionnaire,The changes of electrocardiogram 8 weeks Electrocardiography	—

Measure

Time frame

Working memory test 8 weeks Computerized batteries test ,Acetylcholinesterase and Monoamine oxidase enzyme (MAOA and MAOB) 8 weeks Laboratory,Oxidative stress markers include Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) 8 weeks Laboratory,Serum bone markers include Osteocalcin, Calcium and Beta CTX 8 weeks Laboratory,The changes of hematological and clinical chemistry parameters 8 weeks Laboratory,Stool examination (PH, Total lactic acid, Bifidobacterial, Short chain fatty acid) 8 weeks Laboratory,Evaluation of sleep quality 8 weeks Pittsburgh Sleep Quality Index questionnaire,Evaluation of Stress 8 weeks Perceived Stress Scale - PSS questionnaire,The changes of electrocardiogram 8 weeks Electrocardiography

—

Countries

Thailand

Contacts

Public ContactWipawee Thukhammee

Khon Kaen University

wipath@kku.ac.th0850016805

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026