Healthy conditions Healthy conditions
Conditions
Interventions
Subjects are received the placebo product which has same color and smell look like purple waxy corn functional soup ,Subjects are received the functional soup containing purple waxy corn mixed with he
Placebo,Subjects are received the functional soup containing purple waxy corn mixed with herb at dose of 2 g,Subjects are received the functional soup containing purple waxy corn mixed with herb at do
Sponsors
National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 45-60 years old 2.Healthy perimenopausal and postmenopausal women (< 5 years menstruation cessation) who live in Northeastern of Thailand
Exclusion criteria
Exclusion criteria: 1.Volunteers who have been diagnosed with one of the following; cardiovascular diseases, respiratory diseases, neuropsychological diseases, head injury, diabetes mellitus, liver disease, cancer, autoimmune disease, hematological disorder and gout 2.Volunteers who exposed to pesticides during one week before the test 3.Volunteers who have been Hysterectomy and/or Oophorectomy 4.Volunteers who use hormone or any drug that effect on Hypothalamic Pituitary Gonadal axis 5.Volunteers who require supplements or any drug that effect on the nervous system by order of the doctor before trial 6.Smoking more than 10 pieces/day 7.Drinking alcohol more than 5 times/day 8.Athlete or volunteers who have a regular exercise more than 3 time/weeks 9.Volunteers who participate in other projects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| N100 and P300 Event related evoked potentials (ERPs) Event related evoked potentials (ERPs) | — |
Secondary
| Measure | Time frame |
|---|---|
| Working memory test 8 weeks Computerized battery test ,Acetylcholinesteras, Monoamine oxidase enzyme (MAOA and MAOB) and GABA transaminase 8 weeks laboratory,Antioxidant markers include Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GSH-Px) and Malondialdehyde (MDA) 8 weeks laboratory,Inflammatory markers include C-Reactive protein (CRP), IL-6 and TNF-alpha 8 weeks Elisa method,Circulating histone, Histone acetylase (HAT), Histone deacetylase (HDAC), Histone acetylation and DNA methyltransferase (DNMT) 8 weeks laboratory,CYP3A4 and CYP3A4*22 8 weeks Elisa method,The changes of hematological and clinical chemistry parameters 8 weeks laboratory,Stool examination (PH, Total lactic acid, Bifidobacterial, Short chain fatty acid) 8 weeks laboratory,Evaluation of Sleep Quality and Fatigue 8 weeks questionnaires | — |
Countries
Thailand
Contacts
Public ContactJintanaporn Wattanathorn
Khon Kaen University
Outcome results
None listed