Comparison co-load colloid versus crystalloid to prevent hypotension in the patients undergoing hip or proximal femoral fracture surgery: a randomized controlled trial

Effect of colloid vs crystalloid on incidence of intraoperative hypotension

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210316007

Enrollment

Registered

2021-03-16

Start date

2021-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with hip or proximal fracture undergoing spinal anesthesia Patients with hip or proximal fracture undergoing spinal anesthesia

Interventions

6% Hydroxyethyl starch (130/0.4),Lactated Ringer Solution Acetated Ringer Solution

Experimental Drug,Experimental Drug

Colloid,Crystalloid

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hip or proximal femoral fracture surgery Planned for spinal anesthesia during surgery ASA classification I-III

Exclusion criteria

Exclusion criteria: Coagulopathy Severe aortic stenosis Left ventricular ejection fraction less than 30 percent N-terminal pro-brain natriuretic peptide (NT-proBNP) more than 300 pg/mL Mobitz type 2 second-degree atrioventricular block) or third-degree atrioventricular block Congestive heart failure or pulmonary edema End-stage renal disease or needed of renal replacement therapy Glomerular filtration rate less than 30 mL/min/1.73sqm Allergy or hypersensitivity to hydroxyethyl starch Hyponatremia (serum Na less than 130 mEq/L) During or recent underwent of another trial

Design outcomes

Primary

Measure	Time frame
Incidence of intraoperative hypotension 60 mins Mean arterial blood pressure less than 30 percent from baseline	—

Secondary

Measure	Time frame
Vasopressor requirement 60 mins norepinephrine equivalent dose equals to [norepinephrine (mcg/min) + dopamine (mcg/kg/min)/2] + [epinephrine (mcg/min)] + [phenylephrine (mcg/min)/10],Incidence of acute kidney injury 24 hours Serum creatinine rising over or equal 0.3 mg/dL	—

Countries

Thailand

Contacts

Public ContactSuttasinee Petskul

Faculty of Medicine, Prince of Songkla University

p.suttasinee@gmail.com0954402296

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026