Closed fracture neck of femur Bipolar hemiarthroplasty Hip fracture Topical tranexamic acid intravenous tranexamic acid fracture neck of femur blood loss thromboembolic complications Closed fracture neck of femur Bipolar hemiarthroplasty Hip fracture Topical tranexamic acid intravenous tranexamic acid fracture neck of femur blood loss thromboembolic complications
Conditions
Interventions
Topical tranexamic acid group ,Subjects get intravenous normal saline 100 ml drip in 5 minute before surgery(placebo).
Topical tranexamic acid, mixed tranexamic 3 g in normal saline 100 ml divide 50
Active Comparator Drug,Placebo Comparator Drug
Topical tranexamic acid ,Intravenous tranexamic acid
Sponsors
Ratchasapisek Sompoch
Eligibility
Sex/Gender
All
Age
60 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis fracture neck of femur 2. Age more than 60 years old 3. Household ambulatory 4. Low energy mechanism 5. Complete inform consent.
Exclusion criteria
Exclusion criteria: -1. Allergy to TXA 2. Prior history of thromboembolic disease 3. Prior history of stroke 4. Prior history of ischemic heart disease 5. Prior history of seizure 6. Congenital or acquired coagulopathy 7. Renal or liver dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss calculated total blood loss by Gross formula calculated total blood loss by Gross formula | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood transfusion 72 hours Packed red cell after surgery,Complications 6 months Clinical symptoms | — |
Countries
Thailand
Contacts
Public ContactSaran Tantavisut
Chulalongkorn University
Outcome results
None listed