unilateral primary gonarthrosis osteoarthritis, total knee arthroplasty, Nefopam, morphine sparing effect
Conditions
Interventions
nefopam 20 mg IV drip in 1 h q 6 h,nefopam 80 mg continuous infusion in 24 h
Active Comparator Drug,Active Comparator Drug
intermittent infusion nefopam,continuous infusion nefopam
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. age 18 years and above 2. undergoing primary unilateral total knee arthroplasty 3. weight at least 45 kilograms
Exclusion criteria
Exclusion criteria: 1. patients with seizure or have history of seizure 2. patients with benign prostatic hypertrophy or abnormality of urinary tract 3. close angle glaucoma 4. cardiovascular and cerebrovascular disease 5. creatinine clearance less than 30 ml/min 6. impaired hepatic function 7. have current medications in SSRI, SNRI and TCA 8. psychiatric patients 9. have underlying disease involve abnormality of spine and hip 10. intra-operative complications 11. denied morphine use 12. allergic to any medications in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| morphine consumption at 48 hours milligrams | — |
Secondary
| Measure | Time frame |
|---|---|
| pain score at rest every 4 hours numeric rating scale,adveres drug reactions during study peroid nurse record | — |
Countries
Thailand
Contacts
Public Contactworatanat kachacheewa
Mahidol University
Outcome results
None listed