Comparing efficiency of inhaled Nitrous oxide with intramuscular Pethidine for pain relief during active phase of labor; A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210315002

Enrollment

112

Registered

2021-03-15

Start date

2020-08-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

labour pain labour pain

Interventions

Comparing pain score of inhaled 50 % Nitrous oxide 50% oxygen for pain relief during active phase of labor at 30,60,90,120, minutes -observe side effect -observe APGAR score,Comparing pain score of i

Experimental Drug,Experimental Drug

50 % Nitrous oxide 50% oxygen,pethidine

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Nulliparous age >/=18 years old GA >/= 37 week vaginal delivery planning active phase of first stage of labor (4 cm 80% + regular contraction) no drug allergy of entonox and pethidine requesting pain control

Exclusion criteria

Exclusion criteria: disable pulmonary disease SpO2 < 95 % B12 or methionone deficiency history of pneumothorax pneumocephalus air embolus increase intracranial pressure

Design outcomes

Primary

Measure	Time frame
pain score 30/60/90/120 minutes visual analog score	—

Secondary

Measure	Time frame
neonatal outcome at min 1/5/10 APGAR score	—

Countries

Thailand

Contacts

Public Contactthanathip samitinthu

vajira hospital, Navamindrahiraj University

thanathipnana@gmail.com0858569789

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026