Comparison Effectiveness of Nortriptyline and Placebo in the treatment of Chronic osteoarthritis knee

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210311009

Enrollment

200

Registered

2021-03-11

Start date

2019-05-29

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nortriptyline improving functional outcome in OA patients Nortriptyline gonarthrosis

Interventions

Nortriptyline 25 milligrams 1 tab po hs 90 days Omeprazole 20 mg 1x1 po ac 90 days Diclofemac 25 mg 1x3 po pc 2wk , then 1 tab po pro q 8 hr,Placebo 1 tab po hs 90 days Omeprazole 20 mg 1x1 po ac 90 d

Experimental Drug,Placebo Comparator Drug

Nortriptyline 25 milligrams,Placebo

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: OA knee as ACR criteria with KL II,III for 3 months of clinical pain WOMAC pain score > 20 points presant for study

Exclusion criteria

Exclusion criteria: Contraindicated as NSAIDs Drug allergy

Design outcomes

Primary

Measure	Time frame
WOMAC score 0,1,3 moths WOMAC score	—

Secondary

Measure	Time frame
VAS 0,1,3 months Visual analogue scale	—

Countries

Thailand

Contacts

Public ContactKrittamuk Ompornnuwat

Faculty of Medicine Vajira Hospital, Navamindradhiraj university

krittamuk@nmu.ac.th0909933666

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026