generalized vitiligo vitiligo minocycline Phototherapy
Conditions
Interventions
oral minocycline 100mg per day with Narrowband-UVB phototherapy twice a week for 12 weeks
,placebo of Minocycline with Narrowband-UVB phototherapy twice a week for 12 weeks
Active Comparator Drug,Placebo Comparator Drug
oral minocycline,placebo
Sponsors
Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Subject (man or woman) is older than 18 years old Subject with generalized vitiligo with a body surface area involved >10% Subject is able to recieve phototherapy treatment twice a week for 12 weeks subject is willing to participate in research project with sign the inform consent before attend the study and can be responsible to treatment along total course.
Exclusion criteria
Exclusion criteria: subject has recieved in the 3 month prior to enrolment the following therapies; phototherapy, any immunomodulator, systemic corticosteroids and any antioxidants. subject has recieved the topical treatment (topical corticosteroids, topical vitaminD) within 2 weeks of enrolment. subject has a history of radiotherapy, chemotherapy or immunosuppressive therapy subject has a history of skin cancer,photosensitivity or photomediatied disorders and claustrophobia subject has been diagnosed as renal failure or liver disease. subject has an abnormal liver enzyme test (AST,ALT) ,eGFR<60mg/ml and ANA titer more than 1:160 sudject has a history of allergy to tetracyclines. subject is pregnant(as determined by LMP)or subject is breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the depigmentation and repigmentation of vitiligo Baseline, at the end of 4th, 8th and 12th weeks VItiligo Area Scoring Index score | — |
Secondary
| Measure | Time frame |
|---|---|
| the repigmenation Baseline, at the end of 4th, 8th and 12th weeks Quartile grading scales,disease activity Baseline, at the end of 4th, 8th and 12th weeks Vitiligo Disease Activity Index ,Patient satisfaction Baseline, at the end of 12th weeks Visual analog scales,Quality of life Baseline, at the end of 12th weeks Dermatology Life Quality Index | — |
Countries
Thailand
Contacts
Public ContactNamphet Charoenpongpun
Srinakharinwirot University Skin center
Outcome results
None listed