Diabetic mellitus Diabetic nephropathy Diabetic retinopathy Microalbuminuria Macroalbuminuria diabetes mellitus diabetic retinopathy diabetic nephropathy microalbuminuria macroalbuminuria optical coherence tomography angiography OCTA vessel density intercapillary area
Conditions
Interventions
Diabetic patients without diabetic nephropathy (define as 24-urine albumin less than 30 mg),Diabetic patients with microalbuminuria (define as 24-urine albumin between 30-300 mg),Diabetic patients wit
Diagnostic,Diagnostic,Diagnostic
No DN,Early DN,Late DN
Sponsors
Ratchadapiseksompotch Fund
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Participants aged 18-70 years with a diagnosis of type 2 diabetes mellitus according to diagnostic criteria by the American Diabetes Association 2. History of 24-urine albumin and creatinine testing within 3 months prior the recruitment 3. For no DN group, participants with 24-hour urine albumin <30 mg 4. For early DN group, participant with 24-hour urine albumin 30-300 mg 5. For late DN group, participants with 24-hour urine albumin >300 mg 6. Absence of retinal anomaly other than diabetic retinopathy
Exclusion criteria
Exclusion criteria: 1. History of ocular trauma or surgery other than uncomplicated cataract surgery 2. History corneal disorders, strabismus, nystagmus, uveitis, glaucoma, optic nerve abnormalities, neurological disorders or other abnormalities affecting the visual pathway 3. History of retinal laser treatment or intravitreal anti-vascular growth factor (anti-VEGF) treatment 4. Presence of diabetic macular edema or tractional retinal detachment 5. Media opacities preventing reliable retinal imaging 6. Active urinary tract infection 7. Suspected of any non-diabetic renal diseases 8. End-stage kidney disease requiring dialysis or kidney transplantation 9. Participants who could not cooperate adequately for the OCTA examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vessel density At the beginning of the study Optical coherence tomography angiography and calculated with automated software | — |
Secondary
| Measure | Time frame |
|---|---|
| Intercapillary area At the beginning of the study Optical coherence tomography angiography and calculated with automated software,FAZ area At the beginning of the study Optical coherence tomography angiography and calculated with automated software,Fractal dimension At the beginning of the study Optical coherence tomography angiography and calculated with automated software,Subfoveal choroidal thickness At the beginning of the study Optical coherence tomography angiography and calculated with automated software | — |
Countries
Thailand
Contacts
Public ContactNuntachai Surawatsatien
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed