Parkinson disease Cannabidiol cannabis extract Parkinson disease
Conditions
Interventions
Patient will receive cannabidiol rich cannabis extract (compose of CBD 100.5 mg/ml and THC 3.9 mg/ml) for 8 weeks. Dose escalation is depend on response and side effect.,Patient will receive placebo f
Experimental Drug,Placebo Comparator Drug
cannabidiol rich cannabis extract group,Placebo group
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of Parkinson disease, with a disease severity rating of stage 1 to 4 on the Hoehn and Yahr scale 2. stable medication use
Exclusion criteria
Exclusion criteria: 1. Dementia 2. History of ischemic heart disease or arrythmia 3. History of tobacco or alcoholic use 4. History of psychotic illness 5. History of opioid drug use 6. History of using drug that have drug interaction with cannabis extract 7. History of cannabis use 8. Pregnancy and lactation 9. Abnormal liver function test 10. Abnormal renal function test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease severity 8 weeks Unified Parkinson Disease Rating score | — |
Secondary
| Measure | Time frame |
|---|---|
| Gait and balance 8 weeks Time up and Go test,Gait velocity 8 weeks 10 metres walk test,Balance 8 weeks 5 times sit to stand,Quality of life 8 weeks Health-related quality of life developed by the Euro Quality of life group score,Anxiety and Depression 8 weeks Thai Hospital Anxiety and depression score,Side effect 8 weeks Side effect,laboratory marker 8 weeks laboratory marker | — |
Countries
Thailand
Contacts
Public ContactAuempa Kanjanarangsichai
Buriram Hospital
Outcome results
None listed