Facial melasma Facial Melasma Tranexamic acid Fractional ErbiumYAG Laser
Conditions
Interventions
One side of the face of melasma patient will be randomized and receive fractional erbium:YAG laser treatment followed by tranexamic acid solution apply immediately after laser treatment. ,Another of
Experimental Drug,Placebo Comparator Drug
Sponsors
Sasima Eimpunth, MD
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age more than 18 years old with diagnosis of melasma by board-certified dermatologist 2. Not receive any topical melasma medications within 1 month before the participation 3. Not receive any laser treatments for melasma within 3 months before the participation 4. Can follow the study protocol
Exclusion criteria
Exclusion criteria: 1. Receive any topical melasma medications within 1 month before the participation 2. Receive any laser treatments for melasma within 3 months before the participation 3. Receive any birth control pills or hormonal injections for birth control 4. Receive any estrogen or progesterone treatment 5. History of allergy or any side effects related to tranexamic acid 6. Any skin inflammation or sunburn on the face 7. Any skin infection on the face 8. Pregnancy or lactating woman 9. History of keloids 10. History of heart diseases, valvular heart diseases, or abnormal blood coagulation; for example; deep vein thrombosis, angina, or stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of melasma baseline, week2, 4,8,12,16,20,32 Melasma Area and Severity Index (MASI) score,Mexameter baseline, wk2,4,8,12,16,20,32 Mexameter,Photo evaluation baseline, week2,4,8,12,16,20,32 Clinical photography,Patient evaluation week4,8,12,16,20,32 Visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects baseline, wk2,4,8,12,16,20,32 Clinical | — |
Countries
Thailand
Contacts
Public ContactSasima Eimpunth
Faculty of Medicine Siriraj Hospital
Outcome results
None listed