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A Randomized Controlled Trial of colistin combined with sulbactam : 9 g/day versus 12 g/day in treatment of multi-drugs resistance Acinetobacter baumannii (MDR Acinetobacter baumannii) pneumonia

Clinical outcome in treatment of MDR A.baumannii pneumonia treated with colistin combined with high dose sulbactam : A randomized control trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210227001
Enrollment
152
Registered
2021-02-27
Start date
2019-09-09
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multidrug resistance Acinetobacter baumannii pneumonia MDR A. baumannii Colistin High dose sulbactam

Interventions

Give colistin combined with sulbactam 9-g/d,Give colistin combined with sulbactam 12-g/d
Experimental Drug,Experimental Drug
Colistin combined with sulbactam 9-g/d,Colistin combined with sulbactam 12-g/d

Sponsors

Department of Medicine, Phramongkutklao Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. A. baumannii MDR pneumonia patients 2. Age 18 or over 18 years old

Exclusion criteria

Exclusion criteria: 1. Sputum culture shows mixed organisms 2. Concurrent or coinfection with other organs 3. Not received colistin for empirical treatment 4. Receive colistin >6 calendar days before date of collected sputum 5. Allergy to colistin or sulbactam 6. Previous participated in this trial within 14 days 7. Pregnancy

Design outcomes

Primary

MeasureTime frame
mortality 7 and 28 days mortality rate—

Secondary

MeasureTime frame
ICU day, ventilator day, adverse even until discharge from ICU, off mechanical ventilator, complete treatment length of ICU stay or mechanical ventilator use, adverse drug events—

Countries

Thailand

Contacts

Public ContactChutchawan Ungthammakhun

Phramongklao hospital

rebornhue@gmail.com0969659535

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026