Effect of intraoperative dexmedetomidine intravenous infusion on postoperative morphine consumption after open thoracotomy

Effect of dexmedetomidine ,RCT

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210226003

Enrollment

Registered

2021-02-26

Start date

2019-12-11

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Open thoracotomy open thoracotomy Dexmedetomidine Morphine consumption

Interventions

Intraoperative dexmedetomidine infusion 0.3 mcg/kg/hr start after intubation to skin closure, NSS infusion intraoperative

Active Comparator Drug,Placebo Comparator Drug

Group D,Group P

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. patient undergo open thoracotomy 2. Age 18-65 year 3. ASA physical status I-III

Exclusion criteria

Exclusion criteria: previous ipsilateral opern thoracotomy Dexmedetomidine allergy chronic pain opioid addiction Ejection fraction (EF) less than 35 more than first degree AV block GFR less than 30 Liver failure Alter mental status cannot accept or deny research pyschiatric disorder pregnancy breast feeding

Design outcomes

Primary

Measure	Time frame
Morphine consumption 24 hr PCA	—

Secondary

Measure	Time frame
pain score at rest and movement 2, 6, 12, 24 hr after end of operation numeric rating scale,side effect of dexmedetomidine and morphine 2, 6, 12, 24 hr after end of operation	—

Countries

Thailand

Contacts

Public ContactMukkharin Pojariya

Faculty of Medicine, Khon Kaen University

mukkharinpoj@gmail.com0898628610

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026