Inflammatory cytokine production in primary total knee arthroplasty inflammatory cytokine primary total knee arthroplasty conventional technique computer-assisted technique
Conditions
Interventions
Conventional technique in TKA,Navigation technique in TKA
Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery
conventional technique,Navigation technique
Sponsors
Navamindradhiraj University Research Fund
Eligibility
Sex/Gender
All
Age
56 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. age 56 to 75 years diagnosed with primary knee osteoarthritis 2. radiograph knee show Kellgren, Lawrence score III to IV 3. staged bilateral knee arthroplasty at least 6 months
Exclusion criteria
Exclusion criteria: 1. previous knee surgery 2. previous or recent knee infection 3. underlying disease with cerebrovascular and neuromuscular that affected knee function 4. liver disease, malnutrition, hypoalbuminemia 5. lung complication 6. ESRD, autoimmune disease 7. NSAIDs allergy 8. history of hyaluronic acid usage within 6 months 9. systemic NSAIDs within 15 days 10. drug abuse and alcohol usage within 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum interleukin-6 baseline, 24 h, 72 h, 2 wks pg/ml,joint interleukin-6 baseline, 24 h pg/L,serum ESR baseline, 24 h, 72 h, 2 wks mm/hr,serum CRP baseline, 24 h, 72 h, 2 wks mg/L,joint CRP baseline, 24 h mg/L,skin temperature of knee baseline, 72 h, 2 wks Celsius | — |
Secondary
| Measure | Time frame |
|---|---|
| KOOS 2 wks score | — |
Countries
Thailand
Contacts
Public ContactTheerasak Tempaiboolkul
Faculty of Medicine Vajira Hospital, Navamindradhiraj University
Outcome results
None listed