vaginal atrophy in postmenopausal women Vaginal vitamin D vaginal atrophy postmenopausal women vitamin D
Conditions
Interventions
vitaminD3 1000IU vaginal suppository once daily for 8 weeks ,vitaminD3 1000IU oral administration once daily for 8 weeks
Active Comparator Drug,Active Comparator Drug
vaginal suppository,oral administration
Sponsors
Faculty of Medicine Khon kaen University
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Woman with vaginal atrophy age 45 years old or more who had amenorrhea for at least 1 year or underwent bilateral oophorectomy or who had serum FSH more than 40 IU/ml
Exclusion criteria
Exclusion criteria: 1. who had history hormonal replacement therapy or vitamin D3 used for 12 weeks before enrollment 2. who had abnormal vaginal bleeding for 12 weeks before enrollment 3. who had history used any vaginal suppository or vaginal apply for 4 weeks before enrollment 4. who had history of sexual transmitted disease 5. who had abnormal pap smear 6. hypersensitivity to vitamin D 7. liver or renal failure 8. who had high serum phosphate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the most bothersome symptoms of vaginal atrophy 4 and 8 weeks after intervention severity of symptoms | — |
Secondary
| Measure | Time frame |
|---|---|
| vaginal maturation value 4 and 8 weeks after intervention vaginal maturation value,vaginal pH 4 and 8 weeks after intervention vaginal maturation value,satisfactory 8 weeks after intervention rating scale | — |
Countries
Thailand
Contacts
Public ContactPakapong Kerdtawee
Faculty of Medicine Khon Kaen University
Outcome results
None listed