Patient presented with acute pancreatitis mild severity Mild acute pancreatitis
Conditions
Interventions
The aggressive group receive Ringer lactate solution 20 ml/kg bolus then 3 ml/kg/hr. ,The standard group received Ringer lactate solution 10 ml/kg bolus then 1.5 ml/kg/hr.
Experimental Other,Experimental Other
Aggressive intravenous hydration protocol,Standard intravenous hydration protocol
Sponsors
Department of medicine, Phramongkutklao hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients aged >18 years who admitted to emergency department were diagnosed acute pancreatitis using Revised Atlanta classification defined by two of three following criteria: (1) epigastric abdominal pain, (2) elevated serum amylase and/or lipase greater than 3 times the upper limit of normal, (3) characteristic findings from abdominal imaging.
Exclusion criteria
Exclusion criteria: Exclusion criteria included advanced aged greater than 80 years old, New York Heart Association Class II or greater heart failure, active myocardial ischemia, cardiovascular intervention within previous 60 days, history of cirrhosis, renal insufficiency with creatinine clearance 2 mg/dl). Patients with history of metastasis malignancy, autoimmune disease, chronic infectious disease including human immunodeficiency virus or tuberculosis were excluded because of potential confounding related to inflammatory markers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvement 36 hours decrease in hematocrit, BUN, and serum creatinine from baseline, decrease in epigastric pain level and tolerance of oral intake. | — |
Secondary
| Measure | Time frame |
|---|---|
| development of SIRS 36 hours at least two of the following heart rate 90, WBC 12000, RR 20 Temp 38 C,development of severe pancreatitis 36 hours by Revised Atlanta classification,complication from volume overload 36 hours Clinical and physical examination and imaging,Relief of epigastric pain 36 hours VAS scores | — |
Countries
Thailand
Contacts
Public ContactApirat Angsubhakorn
Phramongkutklao hospital
Outcome results
None listed