Persistent rhinitis (includes allergic rhinitis and non-allergic rhinitis) Allergic rhinitis Non-allergic rhinitis
Conditions
Interventions
Oxymetazoline 2 sprays per nostril twice daily plus mometasone furoate nasal spray 2 sprays per nostril twice daily, with an interval of 5 minutes between each medication for 4 weeks. All the patients
Oxymetazoline plus Fluticasone furoate nasal spray,Placebo plus Fluticasone furoate nasal spray
Sponsors
the Faculty of Medicine, Prince of Songkla University
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 15 and 65 years 2. Had rhinitis symptoms: two or more symptoms of nasal obstruction, rhinorrhea, and sneezing and/or nasal itching 3. persistent symptom for at least 3 months
Exclusion criteria
Exclusion criteria: 1. Had used intranasal or inhaled or systemic steroids within 1 month 2. Had used systemic steroids within 2 months 3. Had used decongestion or antihistamines within 7 days 4. Had undergone sinonasal surgery or immunotherapy 5. Symptoms or physical signs suggestive of renal, hepatic, or cardiovascular disease, concomitant sinusitis, nasal polyposis, and septal deviation. 6. Recent URI within past 4 weeks 7 Contraindication to allergy skin test 8. Current smokers 9. Contraindication to corticosteroids and decongestants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal symptoms At 0, 4 and 6 weeks after treatment nasal symptoms score | — |
Secondary
| Measure | Time frame |
|---|---|
| Nasal and oral peak inspiratory/expiratory flow rate At 0, 4 and 6 weeks after treatment L/min, ratio,Nasal mucocilliary clearance time At 0, 4 and 6 weeks after treatment minutes,Nasal cytology At 0, 4 and 6 weeks after treatment Cells | — |
Countries
Thailand
Contacts
Public ContactVirat Kirtsreesakul
Prince of Songkla University, Thailand
Outcome results
None listed