patients who ere diagnosed as acute closed fracture of tibial shaft and underwent surgery with intramedullary nail platelet-rich plasma, prp, tibia fracture, bone healing, cortex-to-callus ratio, biological augmentation, regenerative medicine
Conditions
Interventions
underwent surgery with closed reduction with internalfixation with intramedullary nail and PRP injection to fracture site,underwent surgery with closed reduction with internalfixation with intramedull
Experimental Drug,Placebo Comparator Drug
PRP group,NSS group
Sponsors
H.R.H. Maha Chakri Sirindhorn Medical Center (MSMC)
H.R.H. Maha Chakri Sirindhorn Medical Center (MSMC)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18-60 years old (2) New case of tibial fracture within 1 week (3) No life threatening conditions (4) No smoking or stop at least 3 months (5) No underlying disease that inhibit bone healing (6) No drug use that involve in calcium regulator (7) Minimum follow-up of 6 month after surgery
Exclusion criteria
Exclusion criteria: (1) Post operative infection (2) Open diaphyseal fracture (3) Traumatic event at the same affected part that need to re-operative (4) Poor compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| size of callus formation 1 to 6 months of follow up Cortex-to-callus ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient reported outcome at 6 months of follow up VAS, EQ-5D-3L, SF-36 | — |
Countries
Thailand
Contacts
Public ContactBhupaak Engkapawastr
H.R.H. Maha Chakri Sirindhorn Medical Center
Outcome results
None listed