Helicobacter pylori infection Helicobacter pylori infection
Conditions
Interventions
Vonoprazan 20mg bid , amoxicillin 1000mg bid, clarithromycin 500 mg bid for 7 day,Omeprazole 20mg bid, amoxicillin 1000mg bid, clarithromycin 500 mg bid for 14 day
Active Comparator Drug,Placebo Comparator Drug
Sponsors
Research department, Rajavithi hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Present with Helicobacter pylori infection: confirm by one or more of the following methods -Urea breath test -Rapid urea test or - Histology 2. Patient agree to joint the project
Exclusion criteria
Exclusion criteria: 1.history of allergy to PPI, vonoprazan, penicillin , clarithromycin 2. Previous H. Pylori eradication therapy 3. History of antibiotic to effect H. Pylori treatment before 1 month 4. History of GI malignancy or surgery 5. Serious cardiovascular, pulmonary, renal, hepatic disorder or malignancy 6. Pregnancy or lactating 7. History of drug or alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate of H. Pylori infection 4-6 week Eradication success was evaluated by 14C-urea breath test at 4-6 weeks after the completion of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event of H. Pylori treatment 3 and 14 days adverse reactions listed in the questionnaires were bitter taste, nausea and vomiting, diarrhea, and fatigue | — |
Countries
Thailand
Contacts
Public ContactRajavithi hospital Rajavithi hospital
Rajavithi hospital
Outcome results
None listed