A comparison of allogenic blood transfusion between acute normovolemic hemodilution and standard care in patient undergoing cardiac surgery: A prospective randomized controlled study

Status

Unknown

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210218006

Enrollment

330

Registered

2021-02-18

Start date

2021-02-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Number of patients receiving transfusion of RBC during hospital stay between acute normovolemic hemodilution and standard care in cardiac surgery patients Acute normovolemic hemodilution Cardiac surgery patients

Interventions

After induction of general anesthesia, a blood volume of at least 450 ml of total blood volume will be removed via a central line and drawn autologous blood units will be numbered and labeled with pat

Experimental Procedure/Surgery,Experimental Procedure/Surgery

Acute normovolemic hemodilution,Standard care

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Aged > 18 years old Signed informed consent Any cardiac surgical intervention on CPB Elective surgery

Exclusion criteria

Exclusion criteria: 1. Medical decision 2. Unstable coronary artery disease : Recent MI (70%) LM coronary artery stenosis 3. Critical preoperative : Hb < 11 g/dL : VT : VF, aborted sudden cardiac death, preoperative cardiac massage : Preoperative ventilation : Hemodynamic instability : Preoperative inotrope : Preoperative IABP : Preoperative LVAD : Preoperative ECMO : Preoperative severe acute renal failure 4. Emergency surgery 5. Pregnancy 6. Therapy with one of following at the time of surgical intervention : DAPT : Antiplatelet drug (except ASA) : Heparin <6h : Tirofiban <8h : Bivalirudin <12h

Design outcomes

Primary

Measure	Time frame
Number of patients receiving transfusion of RBC during hospital stay During hospital stay until discharge Record patients data	—

Secondary

Measure	Time frame
Bleeding complications Postoperative daily until discharge Amount of blood components transfuse, blood test, surgical revision for bleeding,Ischemic complications Postoperative daily until discharge MI, stroke, thromboembolic events,Acute kidney injury Postoperative daily 3 days Serum Creatinine	—

Countries

Thailand

Contacts

Public ContactChananya Wongsopa

Faculty of medicine, Chiang Mai university

amjigojung@gmail.com0871644893

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026