Non-metastatic hepatocellular carcinoma patients requiring major hepatectomy Hepatocellular Carcinoma NK cells activity Anesthetic technique
Conditions
Interventions
Anesthesia was induced with propofol 1-2 mg/kg of LBW and maintained with propofol target-controlled infusion to 4 mg/ml with the Schnider model.,The anesthetic induction was with 6-8% of sevoflurane
Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery
Propofol-based TIVA,Desflurane anaesthesia
Sponsors
Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with non-metastatic HCC 2.Aged 18 to 75 years 3.ASA physical status I-III 4.Scheduled for elective major hepatic resection
Exclusion criteria
Exclusion criteria: 1. Unsuccessful epidural catheter insertion for pain control 2. Patients refusal 3. Diagnosed with recurrent HCC before the research participation 4. Known allergy to medications used in the research protocol 5. Severe systemic diseases such as cardiovascular, respiratory, or endocrine system conditions 6. Frequent users of anxiolytics and opioids 7. Addiction to alcohol or drug abuse 8. Psychiatric conditions 9. Immunocompromised or receive immunosuppressive drugs within 6 months 10. Diagnosed with or family history of malignant hyperthermia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NK cell cytotoxicity 24 hour postoperatively laboratory results | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-6 24 hour postoperatively laboratory results,Interleukin-10 24 hour postoperatively laboratory results,Recurrent rate 2 years postoperatively Whole abdominal CT scan | — |
Countries
Thailand
Contacts
Public ContactKirada Apisutimaitri
Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed