post operative pain after Anterior Cruciate Ligament Reconstruction surgery with Hamstring graft. ACL Reconstruction pain control peri-articular injection multimodal cocktail drug
Conditions
Interventions
Multimodal cocktail drug consists of 0.5% Bupivacaine 100 mg, Ketorolac 30 mg, Adrenaline 0.2 mg and normal saline solution 37 ml. (total volume 60 ml). The multimodal cocktail drug will be injected
Experimental Drug,Placebo Comparator No treatment
Multimodal cocktail drug,Placebo
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed ACL injury that have to be performed ACLR (elective case) 2. Age 18 to 50 years 3. Normal Conciousness 4. Volunteer
Exclusion criteria
Exclusion criteria: 1. ASA classification more than 3 2. Have history drug allergy (Bupivacaine, NSAIDs, Opioid) 3. Have history of UGIB 4. Chronic Kidney Disease stage 3 or GFR < 60 ml/min/1.73 m2 5. Underlying disease Ishemic Heart Disease, Cardio Vascular Disease, Platelet disorder. Coagulopathy 6. Usage of anti-coagulant drug 7. Have contraindication for Spinal Anesthesia or neurologic disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain at 0,6,12,24,48 hours after ACLR surgery Visual Analogue Pain score | — |
Secondary
| Measure | Time frame |
|---|---|
| IV Opioid drug use within 3 days after ACLR surgery amount of IV opioid drug use,functional score within 6 weeks after surgery IKDC score and Lysholm score,time to ambulation within 3 days after ACLR surgery time (hours),1st time IV Opioid use within 3 days after ACLR surgery time (hours),pain at 2 and 6 weeks after ACLR surgery Visual analogue pain score,range of motion of knee at 6 weeks after ACLR surgery degree,length of stay along admission admission days,Nausea/Vomiting within 3 days after ACLR surgery Nausea/Vomiting | — |
Countries
Thailand
Contacts
Public ContactPhanusorn Chancharoenchai
King Chulalongkorn Memorial Hospital
Outcome results
None listed