Mortality of Single Induction Dose of Etomidate versus Ketamine for Emergency Intubation in Sepsis Patients: A Randomized Study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210213001

Enrollment

260

Registered

2021-02-13

Start date

2019-02-12

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis is a common disease in emergency department (ED). Septic patients often require emergency intubation by using rapid-sequence intubation (RSI) intubated sepsis patients ketamine etomidate mortality Rapid sequence intubation

Interventions

Etomidate 0.2-0.3 mg per kg IV stat before intubation,Ketamine 1 mg per kg IV stat before intubation

Active Comparator Drug,Active Comparator Drug

Etomidate,Ketamine

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Evidence of infection (fever, sign or symptom of infection. unexplained hypotension, or blood culture positive) and 2. qSOFA at least 2 points or delta SOFA at least 2 points and 3. Needed emergency intubation in emergency department

Exclusion criteria

Exclusion criteria: 1. Crash airway 2. Have do-not-attempt resuscitation order 3. Severe uncontrolled hypertension (over 180/110 mmHg) 4. Congestive heart failure 5. Evidence of increase intracranial pressure 6. Evidence of adrenal insufficiency

Design outcomes

Primary

Measure	Time frame
Mortality at 24 hours, 7 days, and 28 days after intervention Mortality rate	—

Secondary

Measure	Time frame
Vasopressor at 1 hours after intervention Vasopressor rate	—

Countries

Thailand

Contacts

Public ContactWinchana Srivilaithon

Thammasat University

winchanas@gmail.com66863669260

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026