Nonsteroidal antiinflammatory drugs (NSAID) reduce pain and improve function in hand OA. However nonselective NSAID carry dose-related gastrointestinal (GI) risks. Nonselective NSAID and cyclooxygenase-2 (COX-2)-selective inhibitors alike bear risks of cardiovascular and renal adverse effects. Hand Osteoarthritis OA hand Cetylated fatty acid CFA
Conditions
Interventions
Apply joints that have pain BID,Apply joints that have pain BID
CFA group,Placebo group
Sponsors
Faculty of Medicine, Prince of Songkla University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosed primary hand osteoarthritis by America college of rheumatology criteria 3. Visual analog scale 30-60 mm 4. 1, 2 and 3 Kellgren-Lawrence hand Osteoarthritis grading
Exclusion criteria
Exclusion criteria: 1. History of hand surgery 2. History of hand intraarticular injection 3. Use oral corticosteroids in 3 months 4. Use supplementary drugs such as Glucosamine, Chondroitin and Diacerein in 3 months 5. History of other additional treatment such as hot pack, massage and splint 6. Secondary OA hand 7. Hand skin lesion 8. Pregnancy and lactation 9. NSAIDs and CFA allergy 10. On ASA, anti-platelet and anti-coagulant 11. Creatinine clearance < 30 ml/min
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional index for hand osteoarthritis(FIHOA) 6 weeks Questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analog score 6 weeks Millimeter,Patient global assessment 6 weeks Millimeter,Side effect such as Skin irritation 6 weeks Skin irritation criteria | — |
Countries
Thailand
Contacts
Public ContactSitthiphong Suwannaphisit
Faculty of Medicine, Prince of Songkla University
Outcome results
None listed