paracetamol acetaminophen shivering shivering prophylaxis spinal anesthesia lower abdominal surgery lower extremities surgery paracetamol acetaminophen shivering shivering prophylaxis perioperative shivering spinal anesthesia lower abdominal surgery lower extremities surgery
Conditions
Interventions
paracetamol 1 g. iv drip over 15 minutes before spinal anesthesia ,normal saline iv drip over 15 minutes before spinal anesthesia
Active Comparator Drug,Placebo Comparator No treatment
intravenous paracetamol,placebo
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 18 - 70 years old, ASA physical status 1 - 3, planned surgery under spinal anesthesia, expected duration of surgery less than 4 hours
Exclusion criteria
Exclusion criteria: refuse to participate in the study, pregnancy, liver disease such as cirrhosis and elevated AST or ALT above three times baseline or alcohol abuse, renal disease such as GFR less than 30 ml/min, asthma, baseline body temperature above 37.8 or below 36 degree celsius before surgery, received paracetamol within 6 hours before surgery, received tramadol within 6 hours or pethidine within 4 hours before surgery, history of chronic use of NSAIDs for more than 2 weeks, uroscopy procedure, neurological disease such as Parkinson disease, paracetamol allergy or contraindication of paracetamol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of shivering after spinal anesthesia until 1 hour after the end of surgery shivering score | — |
Secondary
| Measure | Time frame |
|---|---|
| shivering score after spinal anesthesia until 1 hour after the end of surgery shivering score,body temperature after spinal anesthesia until 1 hour after the end of surgery tympanic temperature ,incidence of hypothermia after spinal anesthesia until 1 hour after the end of surgery tympanic membrane temperature ,perioperative morphine use after spinal anesthesia until 1 hour after the end of surgery total perioperative morphine consumption,total dose of perioperative pethidine after spinal anesthesia until 1 hour after the end of surgery total dose of perioperative pethidine ,PONV after spinal anesthesia until 1 hour after the end of surgery incidence of PONV,complication after spinal anesthesia until 1 hour after the end of surgery complication | — |
Countries
Thailand
Contacts
Public ContactDonlaya Srikajonkiat
Faculty of Medicine, Khon Kaen University
Outcome results
None listed