The efficacy of Botulinum Toxin injection between Fiber Optic Laryngoscopy-guided and EMG-guided technic in patient with adductor spasmodic dysphonia

the efficacy of Botulinum Toxin injection between Fiber Optic Laryngoscopy-guided and EMG-guided technic in patient with adductor spasmodic dysphonia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210206003

Enrollment

Registered

2021-02-06

Start date

2020-12-14

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adductor spasmodic dysphonia Spastic dysphonia Botulinum Toxins Laryngoscopic Surgical Procedure Electromyography

Interventions

1. Patient is on supine and neck extension position. 2. Anaesthetic is injected to skin, subcutaneous tissue, and trachea. 3. Electromyographic needle with syringe containing Botulinum toxin is insert

Active Comparator Procedure/Surgery,Experimental Procedure/Surgery

Electromyography-guided technic,Fiber Optic Laryngoscopy-guided technic

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients with Adductor Spasmodic dysphonia diagnosed by voice specialist doctor at Srinagarind hospital, Thailand. 2. Previously injected with Botulinum toxin at least 2 times with the same dosages.

Exclusion criteria

Exclusion criteria: 1. Adductor Spasmodic dysphonia patients with other vocal diseases, such as vocal nodule, vocal polyp, malignancy. 2. Allergy to Botulinum toxin or anaesthetic 3. Previous vocal surgery 4. Severe complications from Botulinum toxin injection, such as aspiration, breathiness

Design outcomes

Primary

Measure	Time frame
Jitter (Voice parameter) before, 6 week,4-6 month after injection % (by computerized speech lab)	—

Secondary

Measure	Time frame
Shimmer (Voice parameter) before, 6 week,4-6 month after injection % (by computerized speech lab),Maximum Phonation Time(pronounce /a/) before, 6 week,4-6 month after injection seconds,Hoarseness before, 6 week,4-6 month after injection visual analog scale,Hoarseness before, 6 week,4-6 month after injection GIRBAS scale,Hoarseness before, 6 week,4-6 month after injection voice handicap index-30 questionnaire,Pain while injection the day of injection visual analog scale,Uncomfortable feeling while injection the day of injection visual analog scale,duration of complication(aspiration,breathiness,aphonia) 4-6 month after injection Patient reported duration(days)	—

Measure

Time frame

Shimmer (Voice parameter) before, 6 week,4-6 month after injection % (by computerized speech lab),Maximum Phonation Time(pronounce /a/) before, 6 week,4-6 month after injection seconds,Hoarseness before, 6 week,4-6 month after injection visual analog scale,Hoarseness before, 6 week,4-6 month after injection GIRBAS scale,Hoarseness before, 6 week,4-6 month after injection voice handicap index-30 questionnaire,Pain while injection the day of injection visual analog scale,Uncomfortable feeling while injection the day of injection visual analog scale,duration of complication(aspiration,breathiness,aphonia) 4-6 month after injection Patient reported duration(days)

—

Countries

Thailand

Contacts

Public ContactTatchapong Pokun

Faculty of Medicine, Khon Kaen University

testpong2@gmail.com0824965628

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026