Incidence of Radiation-induced Hypothyroidism and Parathyroid Dysfunction Following Head and Neck Irradiation: A Single Center Analysis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20210204008

Enrollment

Registered

2021-02-04

Start date

2020-05-04

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who diagnosed head and neck cancer and received curative irradiation as a part of treatment were evaluated serum thyroid and parathyroid functions Radiation Hypothyroidism Parathyroid dysfunction

Interventions

Patients who diagnosed head and neck cancer and received curative irradiation as a part of treatment were evaluated serum thyroid and parathyroid functions and correlated with radiation painting to th

Screening

Patients who diagnosed head and neck cancer and received curative irradiation

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.age 18 to 75 years old at the time of diagnosis 2.completed RT course at least 12 months before laboratory testing of thyroid and parathyroid function 3.treating as curative intent including chemotherapy 4.no distant metastasis 5.postoperative RT was allowed unless the operation was involved the thyroid gland 6.planning radiation treatment using 3D-CRT or IMRT/ IGRT with SIB 7.available of back up treatment plans

Exclusion criteria

Exclusion criteria: 1.disease extending into hypothalamus-pituitary-thyroid axis or any intracranial involvement 2.radiation field involved pituitary fossa 3.pre-existing thyroid or pituitary disease 4.abnormal thyroid or parathyroid detected from imaging before RT 5.previous thyroid surgery 6.previous RT which RT field might include pituitary gland or lower neck 7.previous iodine radioisotope treatment 8.the patients who were not willing to participate the trial

Design outcomes

Primary

Measure	Time frame
Incidence of hypothyroidism after head and neck irradiation at least 12 months before laboratory testing of thyroid function serum thyroid function and correlated with radiation painting to thyroid gland	—

Secondary

Measure	Time frame
Incidence of parathyroid dysfunction after head and neck irradiation at least 12 months before laboratory testing of parathyroid function serum parathyroid function and correlated with radiation painting to parathyroid region	—

Countries

Thailand

Contacts

Public ContactKasira Assavanopakun

Chiang Mai University

mamie.med@gmail.com053935450

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026