The Association between Stool Retention and Gastroesophageal Reflux Frequency in Patients with Overlapping GERD and Chronic Constipation: A Randomized, Crossover Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210203008

Enrollment

Registered

2021-02-03

Start date

2020-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stool retention on Overlapping GERD and Constipation patients GERD Constipation Stool retention Gastroesophageal reflux frequency Gastric accommodation Satiety drink test

Interventions

Rectal emptying by enema,Stool retention

Experimental Drug,No Intervention No treatment

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Moderate to severe typical GER symptoms Chronic constipation with stool frequency less than2 times /week

Exclusion criteria

Exclusion criteria: Previous intra-abdominal surgeries except for appendectomies, IBD patients, stroke, Parkinson disease who impaired consciousness that could not complete the questionnaire, pregnancy, unable to stop taking medications with gastrointestinal motility/sensation effects at least seven days before the study

Design outcomes

Primary

Measure	Time frame
Gastroesophageal reflux frequency End of study pH monitoring	—

Secondary

Measure	Time frame
Maximum tolerated gastric volume End of study Satiety drink test	—

Countries

Thailand

Contacts

Public ContactTiwaporn Thummongkhol

Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University

nropawit_kao@hotmail.com0876193866

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026