Obstructive sleep apnea patients who undergo uvulopalatoplasty. uvulopalatoplasty obstructive sleep apnea pain nefopam
Conditions
Interventions
20 mg of Nefopam solution (100ml) IV drip since the beginning of the operation until 24 hour,NSS solution (100 ml) IV drip since the beginning of the operation until 24 hour
Experimental Drug,Placebo Comparator Drug
Sponsors
Faculty of Medicine Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Body mass index less than 40 kg/m2 Planned for uvulopalatoplasty Able to handle intravenous patient-controlled analgesia device Understand Thai language Intend to participate
Exclusion criteria
Exclusion criteria: Contraindicated for nefopam i.e. epilepsy, glaucoma, currently on MAO inhibitor drugs or SSRI Contraindicated to parecoxib i.e. allergy to sulfonamide, ischemic heart disease, previous stroke Creatinine clearance less than 60 ml/min Cirrhosis; Child-Pugh class B or C Allergic to morphine, lidocaine, parecoxib, etericoxib, paracetamol, dexamethasone Chronic use of opioids or any drug abuse Chronic use or currently of any analgesic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption 24 hour milligram of morphine used | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first analgesia within 24 hours minutes,pain score 30 min numeric rating scale,pain score 1 hour numeric rating scale,pain score 2 hour numeric rating scale,pain score 12 hour numeric rating scale,pain score 24 hour numeric rating scale,pain score 2 days numeric rating scale,pain score 3 days numeric rating scale,pain score 5 days numeric rating scale,pain score 7 days numeric rating scale,pain score 9 days numeric rating scale,pain score 14 days numeric rating scale,pain score 21 days numeric rating scale,Time to first drink within 24 hours hours,Time to first eat within 24 hours minutes,patient satisfaction 24 hour satisfaction score,patient satisfaction 7 days satisfaction score,patient satisfaction 14 days satisfaction score,Quality of life 24 hour EQ5D5L score,Quality of life 7 days EQ5D5L score,quality of life 14 days EQ5D5L score,Side effect : nausea and vomiting 24 hour severity score,Side effect : tachycardia 24 hours yes or no,side effect : drowsiness 24 hours severity score,side effect : urinary incontinence 24 hours yes or no,side effect : delirium 24 hour yes or no | — |
Countries
Thailand
Contacts
Public ContactPeerachatra Mangmeesri
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital
Outcome results
None listed