House dust mite sensitization allergic rhinitis Immunotherapy allergic rhinitis house dust mite sensitization vitamin A vitamin D3 dysfunctional T-reg
Conditions
Interventions
Vitamin A 25,000 IU/week with Vitamin D3 50,000 IU/week,Vitamin D3 50,000 IU/week + Placebo 1 tab/week,Placebo 2 tabs/week
Vitamin A + Vitamin D3,Vitamin D3 + Placebo,Placebo
Sponsors
Department of Medicine, Phramongkutklao hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Allergic rhinitis with house dust mite sensitization (mono- or polysensitization) with or without asthma 2. No previous treatment with immunotherapy, or quit more than 6 month if the patient used to treatment with immunotherapy 3. Vitamin D level < 30 ng/mL 4. Calcium level < 10.5 mg/dL 5. No pregnant/breastfeeding 6. Accept to intake vitamin A and Vitamin D3
Exclusion criteria
Exclusion criteria: 1.Patients have contraindication for Vitamin A or Vitamin D3 intake eg, Allergy to vitamin 2. Uncontrolled asthma 3. Abnormal kidney or liver function 4. Underlying cardiac disease, Immunodeficiency 5. On treatment with immunosuppressive drugs/chemotherapy 6. Pregnant or breastfeeding 7. Already intake vitamin A or vitamin D3 before enrollment 8. Vitamin D level > 80 ng/mL 9. Vitamin A level > 60 mcg/mL 10. Calcium level > 10.5 mg/dL
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal symptoms At 10 week and 20 week after start treatment Total nasal symptoms score, total nasal symptoms/medication score | — |
Secondary
| Measure | Time frame |
|---|---|
| Dysfunctional T-reg At 10 week and 20 week after start treatment Laboratory assessment for Dysfunctional T-reg | — |
Countries
Thailand
Contacts
Public ContactSopit Siriwongmongkol
Phramongkutklao hospital
Outcome results
None listed