postoperative nausea and vomiting after gynecologic laparoscopic surgery Dimenhydrinate nausea vomiting nausea and vomiting PONV postoperative nausea and vomiting
Conditions
Interventions
administer dexamethasone 4mg plus NSS 10 mL after intubation,administer dexamethasone 4mg plus dimenhydrinate 1mg/kg iv max 50 mg after intubation
Experimental Drug,Experimental Drug
NSS 10 mL,dimenhydrinate 1mg/kg iv max 50 mg
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1 Women age 18-60 years old 2 ASA classification I-II 3 undergoing elective gynecologic laparoscopic surgery 4 Non smoker
Exclusion criteria
Exclusion criteria: 1 patients with hypersensitivity or contraindication to the study drugs 2 receiving an antiemetic drug or steroid within 24 hrs before anesthesia 3 History of opioids use 4 Pregnancy 5 Psychologic problems 6 Operation change from laparoscopy to open surgery 7 Refuse to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of postoperative nausea and vomiting at 30, 60 min, 8, 24 hours after surgery 30 min 60 min 8 hours 24 hours postoperative PONV severity grading | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects of dimenhydrinate at 30, 60 min, 8, 24 hours after surgery 30 min 60 min 8 hours 24 hours postoperative drowsiness, dizziness, dryness of mouth | — |
Countries
Thailand
Contacts
Public ContactPapatsara Ritthiwatthanadet
Faculty of Medicine, Khon Kaen University
Outcome results
None listed