alcohol-related cancer probiotic milk acetaldehyde alcohol carcinogen
Conditions
Interventions
150 ml milk fermented by Lactobacillus rhamnosus GG ,150 ml milk containing lactic-acid and flavor imitating the experimental intervention
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
LGG fermented milk,placebo milk
Sponsors
Thailand Science Research and Innovation and Mahidol University
Eligibility
Sex/Gender
Male
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Thai, 2. male, 3. age 20-50 years old, 4. normal vital signs, 5. no uncontrolled systemic diseases or autoimmune diseases, 6. normal blood chemistry (complete blood count, liver and kidney function, lipid and sugar), 7. active (1/*1) or inactive (1/*2) ALDH2 gene (10 subjects of each), 8. able to consume milk, 9. moderate alcohol drinking (less than 2 drinks per day or 14 drinks per week)
Exclusion criteria
Exclusion criteria: 1. drinking alcohol during 1 week before the day of test, 2. having liver diseases (fatty lover, cirrhosis, hepatitis), gout, 3. history of gastrointestinal surgery, 4. alcoholism or alcohol abuse, 5. taking medicines affecting metabolism of alcohol including antibiotics, antidepressants, antihistamines, barbiturates, benzodiazepines, muscle relaxants, anti-inflammatory agents, anti-coagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary acetaldehyde 0, 5, 15, 30, 45, 60, 90, 120, 150, 210 min HPLC,Blood acetaldehyde 0, 5, 15, 30, 45, 60, 90, 120, 150, 210 min HPLC | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of LGG bacterial count in saliva 0, 5, 15, 30, 45, 60, 90, 120, 150, 210 min Selective culture | — |
Countries
Thailand
Contacts
Public ContactDunyaporn Trachootham
Institute of Nutrition, Mahidol University
Outcome results
None listed