axillary sweating Microneedle Transdermal Botulinum Toxin Botox Patch test
Conditions
Interventions
Botox-loaded Dissolvable Microneedles ,Dissolvable microneedles without any active ingredients
Active Comparator Drug,Placebo Comparator Drug
Botox-loaded Dissolvable Microneedles ,Dissolvable microneedles
Sponsors
Material and Bio interface
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. female, aged 18-60 years 2. able to comply with study protocol 3. willingly inform consent
Exclusion criteria
Exclusion criteria: 1. unable to stop previous treatment (washout period of laser/photo is 4 weeks, washout period of topical treatment is 2 weeks) 2. HDSS 2-4 3. have other inflammatory disease/infection at treatment site 4. Pregnant or lactating women 5. allergic to topical anesthesia and iodine 6. heartblock disease 7. immunocompromised patients 8. psychologic patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sweating reduction, determined by score of iodine starch test Day 0 ,Week 1, Week 2, Week 3, Week 4, Week 8, Week 12, Week 16, Week 20, Week 24 iodine starch test | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Satisfaction Week 1, Week 2, Week 3, Week 4, Week 8, Week 12, Week 16, Week 20, Week 24 Patient Satisfaction Score,Pain score Week 1, Week 2, Week 3, Week 4, Week 8, Week 12, Week 16, Week 20, Week 24 Visual analogue scale,Doctor Satisfaction Week 1, Week 2, Week 3, Week 4, Week 8, Week 12, Week 16, Week 20, Week 24 Doctor Satisfaction Score,Side effects Week 1, Week 2, Week 3, Week 4, Week 8, Week 12, Week 16, Week 20, Week 24 Physical examination | — |
Countries
Thailand
Contacts
Public ContactPravit Asawanonda
Chulalongkorn University
Outcome results
None listed