pain in postoperative unilateral total knee arthroplasty patients Pain Total knee arthroplasty multimodal analgesia morphine
Conditions
Interventions
Nefopam 80 mg in NSS 500 ml IV drip rate 20 ml/hr,
Ketorolac 10 mg IV q 6 hr,
paracetamol(500) 1 tab po q 6 hr,
gabapentin(300) 1 tab po tid pc,Morphine 10 mg in NSS 100 ml IV drip rate 0.02mg/kg/hr(0.01 mg/kg/hr if age over 65 years)
Experimental Drug,Experimental Drug
Multimodal analgesia of nefopam,Morphine
Sponsors
Lerdsin hospital
Lerdsin hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Postoperative unilateral total knee arthroplasty patients. 2.Patients whose medial collateral ligament were not released 3.Underwent spinal block without morphine injection to subarachnoid space
Exclusion criteria
Exclusion criteria: 1.Cannot give information about VAS 2.History of knee surgery same side of total knee arthroplasty 3.BMI equal or more than 40 kg/square meters 4.Underlying disease that are contraindicated to nefopam, ketorolac, paracetamol, gabapentin, morphine : chronic liver disease, cardiac or chronic renal failure(GFR < 90 ml/min/1.73m2), psychiatric disorder, alcohol abuse, glaucoma, peptic ulcer, inflammatory bowel disease, established, ischemic heart disease, suicidal idea 5.History of drug allergy to sulfonamides group 6.Allergy to aspirin, NSAIDs, selective COX-2 inhibitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score 2,6,12,24 hours postoperative Visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects and complications from multimodal analgesia and morphine 2,6,12,24 hours postoperative ask for symptoms | — |
Countries
Thailand
Contacts
Public ContactTreechat Veerakulwatana
Lerdsin hospital
Outcome results
None listed